Levels of prolactin in relation to coagulation factors and risk of venous thrombosis

Danka J. F. Stuijver; Jan Debeij; Bregje van Zaane; Olaf M. Dekkers; Jan W. A. Smit; Harry R. Büller; Frits R. Rosendaal; Victor E. A. Gerdes; Suzanne C. Cannegieter

doi:10.1160/TH12-04-0225

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2012; 108(03): 499-507
DOI: 10.1160/TH12-04-0225

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

Levels of prolactin in relation to coagulation factors and risk of venous thrombosis

Results of a large population-based case-control study (MEGA-study)

Danka J. F. Stuijver

¹Department of Internal Medicine, Slotervaart Hospital, Amsterdam, the Netherlands

²Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands

,

Jan Debeij

³Department of Clinical Epidemiology, Leiden University Medical Center, the Netherlands

,

Bregje van Zaane

¹Department of Internal Medicine, Slotervaart Hospital, Amsterdam, the Netherlands

²Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands

,

Olaf M. Dekkers

³Department of Clinical Epidemiology, Leiden University Medical Center, the Netherlands

⁴Department of Endocrinology and Metabolism, Leiden University Medical Center, the Netherlands

,

Jan W. A. Smit

⁴Department of Endocrinology and Metabolism, Leiden University Medical Center, the Netherlands

,

Harry R. Büller

²Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands

,

Frits R. Rosendaal

³Department of Clinical Epidemiology, Leiden University Medical Center, the Netherlands

⁵Department of Thrombosis and Haemostasis, Leiden University Medical Center, the Netherlands

⁶Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, the Netherlands

,

Victor E. A. Gerdes

¹Department of Internal Medicine, Slotervaart Hospital, Amsterdam, the Netherlands

²Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands

,

Suzanne C. Cannegieter

³Department of Clinical Epidemiology, Leiden University Medical Center, the Netherlands

⁵Department of Thrombosis and Haemostasis, Leiden University Medical Center, the Netherlands

› Institutsangaben

Abstract

Summary

The pituitary hormone prolactin is thought to influence coagulation. We aimed to study the relation between prolactin levels, coagulation factors and risk of venous thrombosis (VT). We used data from a large population based case-control study into aetiology of first VT (MEGA-study). Prolactin levels were determined in 2,068 patients with VT and 2,785 age- and sex matched control subjects. The relation between levels of coagulation factors and prolactin was studied among the controls. In addition, odds ratios (OR) and 95% confidence intervals (95%CI) were calculated for the risk of VT for different cut-off points of prolactin levels based on percentiles determined in the controls. Restricted analysis was performed among cases in whom blood was sampled within six months after VT. We found a rise in factor VIII and von Willebrand factor with increasing levels of prolactin in the controls. An increased risk of VT was observed when blood was sampled within six months after thrombosis (OR 2.9, 95%CI 1.1–8.1) for prolactin levels above the 99^th percentile (42.6 μg/l) relative to levels between the 20^th to 80^th percentile. When blood was sampled more than six months after VT no clear association could be observed (OR 1.3, 95%CI 0.7–2.3). In conclusion, we found a modest association between pro-lactin and symptomatic venous thromboembolism, particularly when blood was sampled close to the event. This may be explained by a causal relation or by prolactin being a marker of stress due to the thrombotic event.

Keywords

Coagulation - fibrinolysis - venous thrombosis - risk factors - prolactin

Volltext

Referenzen

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